Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides

被引：5

作者：

Golling, Stephane ^{[1
]}

Hansjacob, Pierre ^{[1
]}

Bami, Nassim ^{[1
]}

Leroux, Frederic R. ^{[1
]}

Donnard, Morgan ^{[1
]}

机构：

[1] Univ Haute Alsace, CNRS, UMR 7042 LIMA, ECPM, F-67000 Strasbourg, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 24期

关键词：

PALLADIUM-CATALYZED ANNULATION; CYCLIZATION; CHEMISTRY; ALKYNES;

D O I：

10.1021/acs.joc.2c02054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper we report the annulation reaction between 2-iodobenzaldehyde derivatives and various ynamides. This palladium-catalyzed reaction leads to rare polysubstituted amino-indenones in good yields with a regioselectivity up to complete. Remarkably, a regiodivergent selectivity has been identified between aryl and alkyl or silyl ynamides, with the first leading mainly to 2-amido-indenones and the second to 3-amido-indenones.

引用

页码：16860 / 16866

页数：7

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