clinical research;
intravascular ultrasound;
miscellaneous;
other imaging modalities;
D O I:
10.4244/EIJ-D-18-00882
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aims: Patients with cyanotic congenital heart disease (CCHD) have been suggested to develop less atherosclerosis than the general population. This study aimed to evaluate the extent of coronary atherosclerosis in patients with CCHD using intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS). Methods and results: Fifteen patients with CCHD (women, 9; median age, 53 years) and 14 acyanotic controls (women, 6; median age, 53 years) were examined with IVUS-NIRS of the right coronary artery (RCA). The patients with CCHD presented with a larger RCA diameter than the controls (external elastic membrane diameter, 6.1 [4.8-6.7] vs. 4.7 [4.1-5.1] mm, respectively; p=0.01). No difference in area stenosis was found between the patients and the controls (15.8% [12.3-19.7] vs. 15.2% [9.5-18.8]; p=0.87). The presence of lipid by NIRS was noted in 43% of patients with CCHD and in 92% of the controls; however, no differences in total or max 4 mm lipid core burden index (LCBI) or in plasma lipid profile were found. Conclusions: Patients with CCHD presented with larger coronary arteries than acyanotic controls. No difference in the degree of area stenosis in the coronary arteries was found between the cyanotic and acyanotic patients; however, a lower proportion of patients with CCHD showed a positive LCBI.
机构:
CORNELL UNIV, NEW YORK HOSP,MED CTR,DIV PEDIAT CARDIOL, 525 E 68TH ST, NEW YORK, NY 10021 USACORNELL UNIV, NEW YORK HOSP,MED CTR,DIV PEDIAT CARDIOL, 525 E 68TH ST, NEW YORK, NY 10021 USA
ENGLE, MA
AMERICAN JOURNAL OF CARDIOLOGY,
1976,
37
(02):
: 283
-
308
机构:
Univ S Florida, All Childrens Hosp, John Hopkins All Childrens Heart Inst, St Petersburg, FL 33701 USAUniv S Florida, All Childrens Hosp, John Hopkins All Childrens Heart Inst, St Petersburg, FL 33701 USA
Freire, Grace
Miller, Michelle S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, All Childrens Hosp, John Hopkins All Childrens Heart Inst, St Petersburg, FL 33701 USAUniv S Florida, All Childrens Hosp, John Hopkins All Childrens Heart Inst, St Petersburg, FL 33701 USA