Dual-wavelength laser speckle imaging to simultaneously access blood flow, blood volume, and oxygenation using a color CCD camera

被引：40
|
作者：
Wang, Jia [1 ,2 ]
Wang, Yaru [1 ,2 ]
Li, Bing [1 ,2 ]
Feng, Danqi [1 ]
Lu, Jinling [1 ,2 ]
Luo, Qingming [1 ,2 ]
Li, Pengcheng [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, Dept Biomed Engn, Key Lab Biomed Photon, Minist Educ, Wuhan 430074, Peoples R China
来源：
OPTICS LETTERS | 2013年 / 38卷 / 18期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
SPECTROSCOPY; MODEL;
D O I：
10.1364/OL.38.003690
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We developed a dual-wavelength laser speckle imaging system using a single industrial-grade color CCD camera with Bayer filters to simultaneously image changes in blood flow, blood volume, and oxygenation. One frame of a color image recorded with dual-wavelength laser illumination provides not only the intensity fluctuation of the speckle pattern, but also the dual-wavelength optical reflectance signal. The method was validated using a tissue phantom and cuff ischemia experiments in the human arm. This system achieves complete time synchronization, unlike conventional time-sharing systems. Compared with a multicamera system, it also avoids the problem of image registration and can be less expensive. (C) 2013 Optical Society of America
引用
收藏
页码：3690 / 3692
页数：3
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