Noninvasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry

被引：40

作者：

Guo, Xinxin ^{[1
]}

Mandelis, Andreas ^{[1
]}

Zinman, Bernard ^{[2
]}

机构：

[1] Univ Toronto, Dept Mech & Ind Engn, Ctr Adv Diffus Wave Technol CADIFT, Toronto, ON M5S 3G8, Canada

[2] Univ Toronto, Samuel Lunenfeld Res Inst, Mt Sinai Hosp, Toronto, ON M5T 3L9, Canada

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 11期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

BLOOD-GLUCOSE; IN-VIVO; HUMAN EPIDERMIS; SPECTROSCOPY; CALIBRATION; MANAGEMENT;

D O I：

10.1364/BOE.3.003012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Noninvasive glucose monitoring will greatly improve diabetes management. We applied Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR) to noninvasive glucose measurements in human skin in vitro in the mid-infrared range. Glucose measurements in human blood serum diffused into a human skin sample (1 mm thickness from abdomen) in the physiological range (21-400 mg/dl) demonstrated high sensitivity and accuracy to meet wide clinical detection requirements. It was found that the glucose sensitivity could be tuned by adjusting the intensity ratio and phase difference of the two laser beams in the WM-DPTR system. The measurement results demonstrated the feasibility of the development of WM-DPTR into a clinically viable noninvasive glucose biosensor. (c) 2012 Optical Society of America

引用

页码：3012 / 3021

页数：10

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