State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis

被引：111
作者：
Kang, Moon Sung [1 ]
Lee, So Yun [2 ]
Kim, Ki Su [2 ]
Han, Dong-Wook [1 ]
机构：
[1] Pusan Natl Univ, Coll Nanosci & Nanotechnol, Dept Cognomechatron Engn, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea
[2] Pusan Natl Univ, Coll Engn, Dept Organ Mat Sci & Engn, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea
来源：
PHARMACEUTICS | 2020年 / 12卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
gold nanoparticle (AuNP); cancer therapy; theragnosis; photothermal treatment (PTT); photodynamic therapy (PDT); cancer imaging; ENHANCED RAMAN-SCATTERING; TARGETED PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; HIGHLY EFFICIENT; DRUG-DELIVERY; IN-VITRO; CONTRAST AGENTS; CELL CARCINOMA; NANORODS; SIZE;
D O I：
10.3390/pharmaceutics12080701
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Research on cancer theragnosis with gold nanoparticles (AuNPs) has rapidly increased, as AuNPs have many useful characteristics for various biomedical applications, such as biocompatibility, tunable optical properties, enhanced permeability and retention (EPR), localized surface plasmon resonance (LSPR), photothermal properties, and surface enhanced Raman scattering (SERS). AuNPs have been widely utilized in cancer theragnosis, including phototherapy and photoimaging, owing to their enhanced solubility, stability, biofunctionality, cancer targetability, and biocompatibility. In this review, specific characteristics and recent modifications of AuNPs over the past decade are discussed, as well as their application in cancer theragnostics and future perspectives. In the future, AuNP-based cancer theragnosis is expected to facilitate the development of innovative and novel strategies for cancer therapy.
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页码：1 / 22
页数：22
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