Copper-catalyzed benzylic C-H amidation of toluene derivatives with N-(8-quinolyl)amides through C(sp3)-H/N-H cross dehydrogenative coupling

被引：2

作者：

Ji, Huihui ^{[1
]}

Wang, Zhigang ^{[1
]}

Zhan, Hongju ^{[2
]}

Fang, Zeguo ^{[1
]}

Zhang, Qian ^{[1
]}

Li, Dong ^{[1
]}

机构：

[1] Hubei Univ Technol, Sch Mat & Chem Engn, New Mat & Green Mfg Talent Intro & Innovat Demonst, Wuhan 430068, Peoples R China

[2] Jingchu Univ Technol, Hubei Prov Key Lab Drug Synth & Optimizat, Jingmen 448000, Peoples R China

来源：

TETRAHEDRON | 2022年 / 127卷

关键词：

Copper; Toluene; Benzylic C-H bond; Amidation; Cross dehydrogenative coupling; AMINO-BETA-LACTAMS; STEREOSELECTIVE-SYNTHESIS; INTRAMOLECULAR AMINATION; SEQUENTIAL MONOARYLATION/AMIDATION; C(SP(3))-H BONDS; SIMPLE ETHERS; FUNCTIONALIZATION; ACTIVATION; ACIDS; PICOLINAMIDES;

D O I：

10.1016/j.tet.2022.133066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient benzylic C-H amidation method was developed through copper-catalyzed C(sp3)-H/N-H cross dehydrogenative coupling between toluene derivatives and N-(8-quinolyl)amides. The 8-quinolyl group directed the activation of N-H bond without influence of quinoline C-H bonds or remote C(sp3)-H bonds. The reaction also showed broad substrate scope with good functional group compati-bility, producing various functionalized N-benzyl tertiary amides.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：8

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