Recent highlights in antimalarial drug resistance and chemotherapy research

被引：82

作者：

Fidock, David A. ^{[1
,2
]}

Eastman, Richard T. ^{[1
]}

Ward, Stephen A. ^{[3
]}

Meshnick, Steven R. ^{[4
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[3] Univ Liverpool Liverpool Sch Trop Med, Dept Mol & Biochem Parasitol, Liverpool L3 5QA, Merseyside, England

[4] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 12期

关键词：

D O I：

10.1016/j.pt.2008.09.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters on this topic that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008 (MAM 2008). After surveying this area of research, we focus on two important questions: what is the molecular contribution of pfcrt to chloroquine resistance, and what is the mechanism of action of artemisinin? We conclude with thoughts about the current state of antimalarial chemotherapy and priorities moving forward.

引用

页码：537 / 544

页数：8

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