Social Cognition and Emotional Assessment (SEA) is a Marker of Medial and Orbital Frontal Functions: A Voxel-Based Morphometry Study in Behavioral Variant of Frontotemporal Degeneration

被引:65
作者
Bertoux, Maxime [1 ,2 ,3 ,4 ]
Volle, Emmanuelle [2 ,3 ]
Funkiewiez, Aurelie [1 ,4 ]
de Souza, Leonardo Cruz [1 ,2 ,3 ,4 ]
Leclercq, Delphine [5 ]
Dubois, Bruno [1 ,2 ,3 ,4 ]
机构
[1] Grp Hosp Pitie Salpetriere, Inst Memoire & Malad Alzheimer, F-75013 Paris, France
[2] Univ Paris 06, Paris, France
[3] INSERM, Inst Cerveau & Moelle Epiniere, UMRS 975, Paris, France
[4] Grp Hosp Pitie Salpetriere, Ctr References Demences Rares, F-75013 Paris, France
[5] Grp Hosp Pitie Salpetriere, Serv Neuroradiol, F-75013 Paris, France
关键词
Frontotemporal dementia; SEA; bvFTD; Theory of mind; Reversal learning; Medial prefrontal cortex; DORSOLATERAL PREFRONTAL CORTEX; HUMAN ORBITOFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; LOBAR DEGENERATION; ALZHEIMERS-DISEASE; DECISION-MAKING; DOUBLE DISSOCIATION; NEURAL MECHANISMS; NEURONAL-ACTIVITY; MENTAL STATE;
D O I
10.1017/S1355617712001300
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study was to explore the cerebral correlates of functional deficits that occur in behavioral variant frontotemporal dementia (bvFTD). A specific neuropsychological battery, the Social cognition & Emotional Assessment (SEA; Funkiewiez et al., 2012), was used to assess impaired social and emotional functions in 20 bvFTD patients who also underwent structural MRI scanning. The SEA subscores of theory of mind, reversal-learning tests, facial emotion identification, and apathy evaluation were entered as covariates in a voxel-based morphometry analysis. The results revealed that the gray matter volume in the rostral part of the medial prefrontal cortex [mPFC, Brodmann area (BA) 10] was associated with scores on the theory of mind subtest, while gray matter volume within the orbitofrontal (OFC) and ventral mPFC (BA 11 and 47) was related to the scores observed in the reversal-learning subtest. Gray matter volume within BA 9 in the mPFC was correlated with scores on the emotion recognition subtest, and the severity of apathetic symptoms in the Apathy scale covaried with gray matter volume in the lateral PFC (BA 44/45). Among these regions, the mPFC and OFC cortices have been shown to be atrophied in the early stages of bvFTD. In addition, SEA and its abbreviated version (mini-SEA) have been demonstrated to be sensitive to early impairments in bvFTD (Bertoux et al., 2012). Taken together, these results suggest a differential involvement of orbital and medial prefrontal subregions in SEA subscores and support the use of the SEA to evaluate the integrity of these regions in the early stages of bvFTD. (JINS, 2012, 18, 972-985)
引用
收藏
页码:972 / 985
页数:14
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