Total Synthesis of Thuggacin B

被引：31

作者：

Bock, Martin

Dehn, Richard

Kirschning, Andreas ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Chim Organ, D-30167 Hannover, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 47期

关键词：

aldol reaction; antibiotics; Sonogashira reaction; total synthesis; tuberculosis;

D O I：

10.1002/anie.200803271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：9134 / 9137

页数：4

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