Total Synthesis of Thuggacin B

被引：31
作者：
Bock, Martin
Dehn, Richard
Kirschning, Andreas [1 ]
机构：
[1] Leibniz Univ Hannover, Inst Chim Organ, D-30167 Hannover, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 47期
关键词：
aldol reaction; antibiotics; Sonogashira reaction; total synthesis; tuberculosis;
D O I：
10.1002/anie.200803271
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9134 / 9137
页数：4
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