Adverse Events in an Integrated Home-Based Treatment Program for MDR-TB and HIV in KwaZulu-Natal, South Africa

被引：24

作者：

Brust, James C. M. ^{[1
,2
]}

Shah, N. Sarita ^{[1
,2
]}

van der Merwe, Theo L. ^{[3
,4
]}

Bamber, Sheila ^{[3
,4
,5
]}

Ning, Yuming ^{[1
,2
]}

Heo, Moonseong ^{[2
,6
]}

Moll, Anthony P. ^{[3
,4
]}

Loveday, Marian ^{[7
,8
]}

Lalloo, Umesh G. ^{[8
]}

Friedland, Gerald H. ^{[9
,10
]}

Gandhi, Neel R. ^{[1
,2
,11
]}

机构：

[1] Montefiore Med Ctr, Dept Med, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Bronx, NY 10467 USA

[3] Philanjalo, Tugela Ferry, South Africa

[4] Church Scotland Hosp, Tugela Ferry, South Africa

[5] Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa

[6] Montefiore Med Ctr, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[7] MRC, Hlth Syst Res Unit, Cape Town, South Africa

[8] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Med, Durban, South Africa

[9] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA

[10] Yale Univ, Sch Med, Dept Epidemiol, New Haven, CT 06510 USA

[11] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 62卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV; multidrug-resistant tuberculosis; side effects; adverse events; resource-limited settings; MULTIDRUG-RESISTANT TUBERCULOSIS; COMMUNITY-BASED THERAPY; HYPOTHYROIDISM;

D O I：

10.1097/QAI.0b013e31828175ed

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a home-based care setting.

引用

页码：436 / 440

页数：5