SELECTIVE DEPLETION OF TUMOR-SPECIFIC REGULATORY T CELLS IN COMBINATION WITH LOW DOSE CHEMOTHERAPY WITH OR WITHOUT PD-1 BLOCKADE IMPROVES ANTI-TUMOR T CELL RESPONSES IN SOLID TUMORS

被引:0
|
作者
Axe, Dorothee Saddier [1 ]
Kuhne, Michelle [1 ]
Jain, Renu [1 ]
Weist, Brian [1 ]
机构
[1] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA
关键词
D O I
10.1136/jitc-2022-SITC2022.0807
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
807
引用
收藏
页码:A843 / A843
页数:1
相关论文
共 50 条
  • [1] Specific PD-1 Deletion on Regulatory T Cells Leads to Enhanced Anti-Tumor Responses
    Aliazis, Konstantinos
    Christofides, Anthos
    Aksoylar, Halil-Ibrahim
    Shah, Rushil
    Pal, Rinku
    Patsoukis, Nikolaos
    Boussiotis, Vassiliki A.
    BLOOD, 2023, 142
  • [2] Clonal replacement of tumor-specific T cells following PD-1 blockade
    Kathryn E. Yost
    Ansuman T. Satpathy
    Daniel K. Wells
    Yanyan Qi
    Chunlin Wang
    Robin Kageyama
    Katherine L. McNamara
    Jeffrey M. Granja
    Kavita Y. Sarin
    Ryanne A. Brown
    Rohit K. Gupta
    Christina Curtis
    Samantha L. Bucktrout
    Mark M. Davis
    Anne Lynn S. Chang
    Howard Y. Chang
    Nature Medicine, 2019, 25 : 1251 - 1259
  • [3] Clonal replacement of tumor-specific T cells following PD-1 blockade
    Yost, Kathryn E.
    Satpathy, Ansuman T.
    Wells, Daniel K.
    Qi, Yanyan
    Wang, Chunlin
    Kageyama, Robin
    McNamara, Katherine L.
    Granja, Jeffrey M.
    Sarin, Kavita Y.
    Brown, Ryanne A.
    Gupta, Rohit K.
    Curtis, Christina
    Bucktrout, Samantha L.
    Davis, Mark M.
    Chang, Anne Lynn S.
    Chang, Howard Y.
    NATURE MEDICINE, 2019, 25 (08) : 1251 - +
  • [4] Depletion of regulatory T cells enhancing the anti-tumor effect of in situ vaccination in solid tumors
    Xie, Ya-Jia
    Tian, Sha
    Huang, Min
    Lu, Lin -Lin
    Liu, Zhong-Qiu
    Chen, Jun-Hui
    Fan, Xing-Xing
    PHARMACOLOGICAL RESEARCH, 2024, 203
  • [5] Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens
    Grimaldi, Alessio
    Cammarata, Ilenia
    Martire, Carmela
    Focaccetti, Chiara
    Piconese, Silvia
    Buccilli, Marta
    Mancone, Carmine
    Buzzacchino, Federica
    Berrios, Julio Rodrigo Giron
    D'Alessandris, Nicoletta
    Tomao, Silverio
    Giangaspero, Felice
    Paroli, Marino
    Caccavale, Rosalba
    Spinelli, Gian Paolo
    Girelli, Gabriella
    Peruzzi, Giovanna
    Nistico, Paola
    Spada, Sheila
    Panetta, Mariangela
    Cecere, Fabiana Letizia
    Visca, Paolo
    Facciolo, Francesco
    Longo, Flavia
    Barnaba, Vincenzo
    COMMUNICATIONS BIOLOGY, 2020, 3 (01)
  • [6] Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens
    Alessio Grimaldi
    Ilenia Cammarata
    Carmela Martire
    Chiara Focaccetti
    Silvia Piconese
    Marta Buccilli
    Carmine Mancone
    Federica Buzzacchino
    Julio Rodrigo Giron Berrios
    Nicoletta D’Alessandris
    Silverio Tomao
    Felice Giangaspero
    Marino Paroli
    Rosalba Caccavale
    Gian Paolo Spinelli
    Gabriella Girelli
    Giovanna Peruzzi
    Paola Nisticò
    Sheila Spada
    Mariangela Panetta
    Fabiana Letizia Cecere
    Paolo Visca
    Francesco Facciolo
    Flavia Longo
    Vincenzo Barnaba
    Communications Biology, 3
  • [7] Tumor specific γδ T cells expand and respond to PD-1 blockade
    Lien, Scott C.
    Ly, Dalam
    Yang, S. Y. Cindy
    Wang, Ben X.
    St Paul, Michael
    Gadalla, Ramy
    Noamani, Babak
    Boross-Harmer, Sarah
    Pugh, Trevor J.
    Spreafico, Anna
    Hirano, Naoto
    Razak, Albiruni R. A.
    Ohashi, Pamela S.
    CANCER IMMUNOLOGY RESEARCH, 2023, 11 (12)
  • [8] PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?
    Simon, Sylvain
    Labarriere, Nathalie
    ONCOIMMUNOLOGY, 2018, 7 (01):
  • [9] PD-1 BLOCKADE ADMINISTERED BEFORE OR AT THE TIME OF T CELL ACTIVATION ENHANCES ANTI-TUMOR IMMUNITY
    Moseman, Jena
    McNeel, Douglas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A492 - A492
  • [10] Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain
    Robert M. Prins
    Chengyi J. Shu
    Caius G. Radu
    Dan D. Vo
    Haumith Khan-Farooqi
    Horacio Soto
    Meng-Yin Yang
    Muh-Shi Lin
    Stephanie Shelly
    Owen N. Witte
    Antoni Ribas
    Linda M. Liau
    Cancer Immunology, Immunotherapy, 2008, 57 : 1279 - 1289