Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2

被引：2
|
作者：
Artyukhov, V. G. [1 ]
Tyunina, O. I. [2 ]
机构：
[1] Voronezh State Univ, Voronezh, Russia
[2] NN Burdenko Voronezh State Med Univ, Voronezh, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 03期
关键词：
carbon monoxide; lymphocytes; recombinant interleukin-2; Bcl-2; survivin; DEATH;
D O I：
10.1007/s10517-017-3616-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
引用
收藏
页码：362 / 365
页数：4
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