Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2

被引：2

作者：

Artyukhov, V. G. ^{[1
]}

Tyunina, O. I. ^{[2
]}

机构：

[1] Voronezh State Univ, Voronezh, Russia

[2] NN Burdenko Voronezh State Med Univ, Voronezh, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 03期

关键词：

carbon monoxide; lymphocytes; recombinant interleukin-2; Bcl-2; survivin; DEATH;

D O I：

10.1007/s10517-017-3616-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).

引用

页码：362 / 365

页数：4

共 50 条

[31] IN-VITRO AND IN-VIVO CYTOGENETIC EFFECTS OF RECOMBINANT INTERLEUKIN-2 ON HUMAN-LYMPHOCYTES
SHINKAI, T
TAMURA, T
SANO, T
KOJIMA, A
EGUCHI, K
SASAKI, Y
OHE, Y
SAIJO, N
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1994, 17 (01): : 50 - 54
[32] CHARACTERIZATION OF HUMAN INTERFERON-GAMMA AND HUMAN INTERLEUKIN-2 FROM RECOMBINANT MAMMALIAN-CELL LINES AND PERIPHERAL-BLOOD LYMPHOCYTES
RISKE, FJ
CULLEN, BR
CHIZZONITE, R
LYMPHOKINE AND CYTOKINE RESEARCH, 1991, 10 (03): : 213 - 218
[33] CHARYBDOTOXIN INHIBITS PROLIFERATION AND INTERLEUKIN-2 PRODUCTION IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES
PRICE, M
LEE, SC
DEUTSCH, C
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) : 10171 - 10175
[34] SPONTANEOUS EXPRESSION OF THE INTERLEUKIN-2 RECEPTOR GENE AND PRESENCE OF FUNCTIONAL INTERLEUKIN-2 RECEPTORS ON LYMPHOCYTES-T IN THE BLOOD OF INDIVIDUALS WITH ACTIVE PULMONARY SARCOIDOSIS
KONISHI, K
MOLLER, DR
SALTINI, C
KIRBY, M
CRYSTAL, RG
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (03): : 775 - 781
[35] LARGE ANTIGRANULOCYTES LYMPHOCYTES FROM SCID HORSES DEVELOP POTENT CYTOTOXIC ACTIVITY AFTER TREATMENT WITH HUMAN RECOMBINANT INTERLEUKIN-2
MAGNUSON, NS
PERRYMAN, LE
WYATT, CR
MASON, PH
TALMADGE, JE
JOURNAL OF IMMUNOLOGY, 1987, 139 (01): : 61 - 67
[36] INVIVO ACTIVATED CORD BLOOD-LYMPHOCYTES EXPRESS HIGH-AFFINITY INTERLEUKIN-2 RECEPTOR - EVALUATION OF THEIR RESPONSIVENESS TO INVITRO STIMULATION WITH RECOMBINANT INTERLEUKIN-2
MONTAGNA, D
MORETTA, A
MARCONI, M
MINGRAT, G
GASPARONI, A
GIAROLA, M
MACCARIO, R
BIOLOGY OF THE NEONATE, 1992, 62 (06): : 385 - 394
[37] HUMAN RECOMBINANT INTERLEUKIN-2(125) INDUCED INVITRO PROLIFERATION OF EQUINE, CAPRINE, OVINE, CANINE AND FELINE PERIPHERAL-BLOOD LYMPHOCYTES
FENWICK, BW
SCHORE, CE
OSBURN, BI
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1988, 11 (01) : 51 - 60
[38] INTERLEUKIN-4 REGULATES THE INTERLEUKIN-2 RECEPTORS ON HUMAN PERIPHERAL-BLOOD LYMPHOCYTES-B
TOMIZAWA, K
ISHIZAKA, A
KOJIMA, K
NAKANISHI, M
SAKIYAMA, Y
MATSUMOTO, S
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 83 (03): : 492 - 496
[39] ANTITUMOR-ACTIVITY AND SURFACE PHENOTYPES OF HUMAN GLIOMA-INFILTRATING LYMPHOCYTES AFTER INVITRO EXPANSION IN THE PRESENCE OF INTERLEUKIN-2
SAWAMURA, Y
HOSOKAWA, M
KUPPNER, MC
KOBAYASHI, H
AIDA, T
ABE, H
DETRIBOLET, N
CANCER RESEARCH, 1989, 49 (07) : 1843 - 1849
[40] ADOPTIVE IMMUNOTHERAPY USING HUMAN RECOMBINANT INTERLEUKIN-2 ACTIVATED SPECIFIC CYTOTOXIC T-LYMPHOCYTES
SURESH, K
NIRMALA, K
VASUDEVAN, DM
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 1990, 9 (03) : 155 - 160

← 1 2 3 4 5 →