Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2

被引：2
作者：
Artyukhov, V. G. [1 ]
Tyunina, O. I. [2 ]
机构：
[1] Voronezh State Univ, Voronezh, Russia
[2] NN Burdenko Voronezh State Med Univ, Voronezh, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 03期
关键词：
carbon monoxide; lymphocytes; recombinant interleukin-2; Bcl-2; survivin; DEATH;
D O I：
10.1007/s10517-017-3616-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
引用
收藏
页码：362 / 365
页数：4
相关论文
共 15 条
  • [1] ARMANT M, 1995, IMMUNOLOGY, V85, P331
  • [2] Artyukhov V. G., 2014, Radiatsionnaya Biologiya Radioekologiya, V54, P297, DOI 10.7868/S0869803114030047
  • [3] Artyukhov V. G., 2012, Radiatsionnaya Biologiya Radioekologiya, V52, P534
  • [4] Catty D, 1991, ANTIBODIES PRACTICAL
  • [5] Chechina O. E., 2011, Immunologiya, V32, P127
  • [6] Granberg II, 2002, ORGANIC CHEM
  • [7] ACTIVATION-INDUCED APOPTOSIS IN LYMPHOCYTES
    GREEN, DR
    SCOTT, DW
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1994, 6 (03) : 476 - 487
  • [8] Cytokine mediated apoptosis of granulocyte eosinophils in expressed blood eosiniphilia
    Litvinova L.S.
    Ryazantseva N.V.
    Novitskii V.V.
    Grigoreva E.S.
    [J]. Cell and Tissue Biology, 2008, 2 (1) : 33 - 37
  • [9] BCL-2 family members and the mitochondria in apoptosis
    Gross, A
    McDonnell, JM
    Korsmeyer, SJ
    [J]. GENES & DEVELOPMENT, 1999, 13 (15) : 1899 - 1911
  • [10] Interactions of Multiple Gas-Transducing Systems: Hallmarks and Uncertainties of CO, NO, and H2S Gas Biology
    Kajimura, Mayumi
    Fukuda, Ryo
    Bateman, Ryon M.
    Yamamoto, Takehiro
    Suematsu, Makoto
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (02) : 157 - 192
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