Feasibility of Using Biomarkers in Blood Serum as Markers of Effect Following Exposure of the Lungs to Particulate Matter Air Pollution

被引：16
作者：
Elvidge, Timothy [1 ]
Matthews, Ian P. [1 ]
Gregory, Clive [1 ]
Hoogendoorn, Bastiaan [1 ]
机构：
[1] Cardiff Univ, Cochrane Inst Primary Care & Publ Hlth, Sch Med, Cardiff CF14 4YS, S Glam, Wales
来源：
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS | 2013年 / 31卷 / 01期
关键词：
particulate matter; air pollution; serum biomarkers; epidemiologic studies; oxidative stress; human health effects; exposure assessment; C-REACTIVE PROTEIN; DIESEL-EXHAUST INHALATION; AFFECT VASCULAR FUNCTION; OXIDATIVE-STRESS; ULTRAFINE PARTICLES; CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; ENDOTHELIAL DYSFUNCTION; CIRCULATING BIOMARKERS; ASTHMATIC VOLUNTEERS;
D O I：
10.1080/10590501.2013.763575
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Particulate matter (PM) air pollution has significant cardiopulmonary health effects. Serum biomarkers may elucidate the disease mechanisms involved and provide a means for biomonitoring exposed populations, thereby enabling accurate policy decisions on air quality standards to be made. For this review, research investigating association of blood serum biomarkers and exposure to PM was identified, finding 26 different biomarkers that were significantly associated with exposure. Recent evidence links different effects to different components of PM. Future research on biomarkers of effect will need to address exposure by all PM size fractions.
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页码：1 / 44
页数：44
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