Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients

被引：30

作者：

Gi, R. E. A. Tjon Pian ^{[1
]}

Ilmarinen, T. ^{[2
]}

van den Heuvel, E. R. ^{[3
]}

Aaltonen, L. M. ^{[2
]}

Andersen, J. ^{[4
]}

Brunings, J. W. ^{[5
]}

Chirila, M. ^{[6
]}

Dietz, A. ^{[7
]}

Ferran Vila, F. ^{[8
]}

Friedrich, G. ^{[9
]}

de Gier, H. H. W. ^{[10
]}

Golusinski, W. ^{[11
]}

Graupp, M. ^{[9
]}

Hantzakos, A. ^{[12
]}

Horcasitas, R.

Jackowska, J. ^{[13
]}

Koelmel, J. C. ^{[14
]}

Lawson, G. ^{[15
]}

Lindner, F. ^{[7
]}

Remacle, M. ^{[15
]}

Sittel, C. ^{[14
]}

Weichbold, V. ^{[16
]}

Wierzbicka, M. ^{[13
]}

Dikkers, F. G. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands

[2] Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

[4] Reg Hosp Viborg, Ear Nose Throat Dept, Viborg, Denmark

[5] Maastricht Univ, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Maastricht, Netherlands

[6] Univ Med & Pharm, Cluj Napoca Emergency Cty Hosp, ENT Dept, Cluj Napoca, Romania

[7] Univ Leipzig, Dept Otorhinolaryngol, D-04109 Leipzig, Germany

[8] Hosp Gral de Catalunya St Cugat del Valles, Dept Otorhinolaryngol, Barcelona, Spain

[9] Med Univ Graz, Dept Otorhinolaryngol, Graz, Austria

[10] Erasmus Univ, Dept Otorhinolaryngol Head & Neck Surg, Rotterdam, Netherlands

[11] Greater Poland Canc Ctr, Dept Otorhinolaryngol, Poznan, Poland

[12] Univ Athens, Hippocrate Gen Hosp, Dept Otorhinolaryngol 1, Athens, Greece

[13] Poznan Univ Med Sci, Dept Otolaryngol, Poznan, Poland

[14] Katharinen Hosp, Klinikum Stuttgart, Dept Otorhinolaryngol Head & Neck Surg, D-70174 Stuttgart, Germany

[15] Univ Hosp Louvain Mt Godinne, Dept Otorhinolaryngol, Yvoir, Belgium

[16] Med Univ Innsbruck, Dept Hearing Speech & Voice Disorders, A-6020 Innsbruck, Austria

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2013年 / 270卷 / 05期

关键词：

Recurrent respiratory papillomatosis; RRP; Laryngeal papilloma; Cidofovir; Side effects; Nephrotoxicity; Neutropenia; Malignancy; HUMAN-PAPILLOMAVIRUS; JUVENILE-ONSET; RISK-FACTORS; LARYNGEAL PAPILLOMAS; CLINICAL-COURSE; POPULATION; PREVALENCE; CHILDREN; THERAPY; DISEASE;

D O I：

10.1007/s00405-013-2358-7

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Intralesional use of cidofovir (Vistide(A (R))) has been one of the mainstays of adjuvant therapy in patients with recurrent respiratory papillomatosis (RRP) since 1998. In 2011, a communication provided by the producer of cidofovir addressed very serious side effects concerning its off-label use. As this was a general warning, it was inconclusive whether this would account for its use in RRP. The aim of this study is to determine whether nephrotoxic, neutropenic, or oncogenic side effects have occurred after intralesional use of cidofovir in patients with RRP. Update of recent developments in RRP, a multicentre questionnaire and a multicentre retrospective chart review. Sixteen hospitals from eleven countries worldwide submitted records of 635 RRP patients, of whom 275 were treated with cidofovir. RRP patients received a median of three intralesional injections (interquartile range 2-6). There were no statistical differences in occurrence of neutropenia or renal dysfunction before and after cidofovir. There was no statistical difference in occurrence of upper airway and tracheal malignancies between the cidofovir and the non-cidofovir group. In this retrospective patient chart review, no clinical evidence was found for more long-term nephrotoxicity, neutropenia or laryngeal malignancies after the administration of intralesional cidofovir in RRP patients.

引用

页码：1679 / 1687

页数：9

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