Zebrafish and Xenopus tadpoles:: Small animal models to study angiogenesis and lymphangiogenesis

被引：51

作者：

Ny, A ^{[1
]}

Autiero, M ^{[1
]}

Carmeliet, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Flinders Interuniv Inst Biotechnol, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 05期

关键词：

angiogenesis; lymphangiogenesis; zebrafish; Xenopus;

D O I：

10.1016/j.yexcr.2005.10.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in angiogenesis and lymph angiogenesis-a significant task with a consequent impact on the design of more effective therapeutic strategies. The advantages of these two models will be discussed in the present review. (c) 2005 Elsevier Inc. All rights reserved.

引用

收藏

页码：684 / 693

页数：10

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