Development of a novel liquid chromatography-tandem mass spectrometric method for aristolochic acids detection: Application in food and agricultural soil analyses

被引:43
作者
Chan, Chi-Kong [1 ]
Pavlovic, Nikola M. [2 ]
Chan, Wan [1 ]
机构
[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
[2] Serbian Med Soc, Branch Nis, Nish 18000, Serbia
关键词
Aristolochic acids; Aristolactams; Dietary exposure; Food poisoning; Balkan endemic nephropathy; Nitroreduction; LC-MS/MS; BALKAN ENDEMIC NEPHROPATHY; CHINESE HERBS NEPHROPATHY; MEDICINAL-PLANTS; EXPOSURE; ETIOLOGY; REMEDIES; ARISTOLOLACTAMS; SAMPLES; CANCER;
D O I
10.1016/j.foodchem.2019.03.073
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Prolonged dietary exposure to AA-contaminated food crops cultivated in contaminated farmland was shown to be one of the main culprits of Balkan endemic nephropathy. Ultra-sensitive methods for the detection of AA at trace levels are important for surveillance purposes. We report the development of a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for AA-detection. One striking feature of the method is that the Zn/H+-induced nitroreduction convert AA into their respective aristolactams, which dramatically enhances their analytical sensitivity. The method was applied to quantitate AA in food grains and soil samples collected from farming villages of Serbia, and flour samples purchased from supermarkets. To the best of our knowledge, this is the first report of detecting AA in food ingredients available in supermarkets, which is alarming because it reveals AA poses insidious threats not only to residents of rural farming villages, but also to people residing in urban areas.
引用
收藏
页码:673 / 679
页数:7
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