Global analysis of clinical trials with probiotics

被引：74

作者：

Dronkers, Theresia M. G. ^{[1
]}

Ouwehand, Arthur C. ^{[3
]}

Rijkers, Ger T. ^{[1
,2
]}

机构：

[1] Univ Coll Roosevelt, Dept Sci, Lange Noordstr 1, NL-4331 CB Middelburg, Netherlands

[2] St Elizabeth Hosp, Lab Med Microbiol & Immunol, Tilburg, Netherlands

[3] Danisco Sweeteners Oy, DuPont Nutr & Biosci, Kantvik 02460, Finland

来源：

HELIYON | 2020年 / 6卷 / 07期

关键词：

Prebiotics; Probiotics; Bacteria; Microorganism; Digestive system; Immunology; Immune system; Microbiota; Clinical trials; STATEMENT;

D O I：

10.1016/j.heliyon.2020.e04467

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Over 1,000 clinical studies with probiotics, registered at ClinicalTrials.gov and/or the International Clinical Trials Registry Platform (ICTRP) of the World Health Organization, have addressed over 700 different diseases and conditions. The average size of a clinical trial with probiotics (74 participants) is comparable to the overall average of all studies in ClincialTrials.gov. Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis ssp. lactis BB12 are the probiotic strains studied most. The exact composition of the product which is used, including the dosage, is not always indicated in the registry. The majority of probiotics studies at ClinicalTrials.gov is registered in the USA or Europe (56%). The data from ICTRP show the rapid expansion of clinical studies with probiotics in Asia, notably Iran and China.

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