A short and convenient strategy for the synthesis of pyridazines via Diaza-Wittig reaction

被引：14

作者：

Abed, Hassen Bel ^{[1
]}

Mammoliti, Oscar ^{[2
]}

Van Lommen, Guy ^{[2
]}

Herdewijn, Piet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Med Chem Lab, Rega Inst Med Res, B-3000 Louvain, Belgium

[2] Galapagos, Med Chem Lab, B-2800 Mechelen, Belgium

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 48期

关键词：

Pyridazine; Diaza-Wittig; Diazo transfer reaction; Weiler dianion; DIELS-ALDER REACTIONS; NUCLEOPHILIC-ADDITION; CARBONYL-COMPOUNDS; ONE-POT; CONSTRUCTION; DERIVATIVES; INHIBITORS; CASCADE; DESIGN;

D O I：

10.1016/j.tetlet.2012.09.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and selective synthesis of 6-substituted-4-hydroxy-3-methoxycarbonyl pyridazines has been developed via a diaza-Wittig reaction. The desired products substituted at the C6 position can be obtained from readily available starting materials under mild conditions. This represents an attractive new method for the synthesis of pyridazine derivatives. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6489 / 6491

页数：3

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