Recombinant allergens The present and the future

被引：25
作者：
Jutel, Marek [1 ]
Solarewicz-Madejek, Katarzyna [1 ]
Smolinska, Sylwia [1 ]
机构：
[1] Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2012年 / 8卷 / 10期
关键词：
allergy; allergen-specific immunotherapy; recombinant allergens; hypoallergens; vaccines; HOUSE-DUST MITE; BIRCH POLLEN ALLERGEN; COMPONENT-RESOLVED DIAGNOSTICS; T-CELL PEPTIDES; GRASS-POLLEN; CROSS-REACTIVITY; FOLLOW-UP; IMMUNOTHERAPY; CAT; EPITOPE;
D O I：
10.4161/hv.22064
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Allergen specific immunotherapy (SIT) is the only known causative treatment of allergic diseases. Recombinant allergen-based vaccination strategies arose from a strong need to both to improve safety and enhance efficacy of SIT. In addition, new vaccines can be effective in allergies including food allergy or atopic dermatitis, which poorly respond to the current treatment with allergen extracts. A number of successful clinical studies with both wild-type and hypoallergenic derivatives of recombinant allergens vaccines have been reported for the last decade. They showed high efficacy and safety profile as well as very strong modulation of T and B cell responses to specific allergens.
引用
收藏
页码：1534 / 1543
页数：10
相关论文
共 72 条
[61]   Characterization and immunobiology of house dust mite allergens [J].
Thomas, WR ;
Smith, WA ;
Hales, BJ ;
Mills, KL ;
O'Brien, RM .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2002, 129 (01) :1-18
[62]   Mechanisms of allergen-specific desensitization [J].
Uermoesi, Christina ;
Beerli, Roger R. ;
Bauer, Monika ;
Manolova, Vania ;
Dietmeier, Klaus ;
Buser, Regula B. ;
Kuendig, Thomas M. ;
Saudan, Philippe ;
Bachmann, Martin F. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (02) :375-383
[63]   Recombinant allergens for allergen-specific immunotherapy: 10 years anniversary of immunotherapy with recombinant allergens [J].
Valenta, R. ;
Linhart, B. ;
Swoboda, I. ;
Niederberger, V. .
ALLERGY, 2011, 66 (06) :775-783
[64]  
Valenta R, 1999, CLIN EXP ALLERGY, V29, P896
[65]   Recombinant allergens: What does the future hold? [J].
Valenta, Rudolf ;
Niespodziana, Katarzyna ;
Focke-Tejkl, Margit ;
Marth, Katharina ;
Huber, Hans ;
Neubauer, Angela ;
Niederberger, Verena .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (04) :860-864
[66]   Identification, characterization, and cloning of a complementary DNA encoding a 60-kd house dust mite allergen (Der f 18) for human beings and dogs [J].
Weber, E ;
Hunter, S ;
Stedman, K ;
Dreitz, S ;
Olivry, T ;
Hillier, A ;
McCall, C .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 112 (01) :79-86
[67]   Cross-reactivity of pollen allergens: impact on allergen immunotherapy [J].
Weber, Richard W. .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2007, 99 (03) :203-212
[68]   Different allergenic activity of grass pollen allergens revealed by skin testing [J].
Westritschnig, K. ;
Horak, F. ;
Swoboda, I. ;
Balic, N. ;
Spitzauer, S. ;
Kundi, M. ;
Fiebig, H. ;
Suck, R. ;
Cromwell, O. ;
Valenta, R. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2008, 38 (04) :260-267
[69]   Safety and Tolerability of Recombinant Bet v 1 (rBet v 1) Tablets in Sublingual Immunotherapy (SLIT) [J].
Winther, L. ;
Poulsen, L. K. ;
Robin, B. ;
Melac, M. ;
Malling, H. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (02) :S215-S215
[70]   YEAST RNA POLYMERASE-II GENES - ISOLATION WITH ANTIBODY PROBES [J].
YOUNG, RA ;
DAVIS, RW .
SCIENCE, 1983, 222 (4625) :778-782
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