SOLUTION THERMODYNAMICS OF METHOCARBAMOL IN SOME ETHANOL plus WATER MIXTURES

被引：7
|
作者：
Mercado, Katia C. [1 ]
Rodriguez, Gerson A. [1 ]
Delgado, Daniel R. [1 ]
Martinez, Fleming [1 ]
Romdhani, Asma [2 ]
机构：
[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Bogota, DC, Colombia
[2] Univ Monastir, Fac Pharm, Monastir, Tunisia
来源：
QUIMICA NOVA | 2012年 / 35卷 / 10期
关键词：
cosolvency; methocarbamol; solubility; ENTHALPY-ENTROPY COMPENSATION; PREFERENTIAL SOLVATION; SOLUBILITY; KETOPROFEN; MELOXICAM;
D O I：
10.1590/S0100-40422012001000015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric values of drug fusion. The drug solubility was greatest in the mixtures with 0.70 or 0.80 mass fraction of ethanol and lowest in neat water across all temperatures studied. Non-linear enthalpy-entropy compensation was found for the dissolution processes. Accordingly, solution enthalpy drives the respective processes in almost all the solvent systems analyzed.
引用
收藏
页码：1967 / 1972
页数：6
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