Discovery of Schaeffer's Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach

被引：11
作者：
Schmidt, Marco F. [1 ]
Korb, Oliver [2 ]
Howard, Nigel I. [1 ]
Dias, Marcio V. B. [3 ]
Blundell, Tom L. [3 ]
Abell, Chris [1 ]
机构：
[1] Univ Cambridge, Univ Chem Lab, Cambridge CB2 1EW, England
[2] CCDC, Cambridge CB2 1EZ, England
[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
来源：
CHEMMEDCHEM | 2013年 / 8卷 / 01期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
antibiotics; drug design; drug discovery; molecular modeling; Mycobacterium tuberculosis; SCORING FUNCTIONS; SPECIFICITY; RECOGNITION; POTENT; SITES;
D O I：
10.1002/cmdc.201200508
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：54 / 58
页数：5
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