Direct monoalkylation of alkyl phosphinates to access H-phosphinic acid esters

被引：18

作者：

Abrunhosa-Thomas, I ^{[1
]}

Ribière, P ^{[1
]}

Adcock, AC ^{[1
]}

Montchamp, JL ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Chem, Ft Worth, TX 76129 USA

来源：

SYNTHESIS-STUTTGART | 2006年 / 02期

关键词：

phosphorus; H-phosphinic acid; phosphinates; alkylation; hypophosphite;

D O I：

10.1055/s-2005-924768

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple alkyl phosphinates prepared by the silicate esterification method can be alkylated under Barbier-like conditions with butyl lithium at -78 degrees C followed by warming to room temperature. The method is limited to the more reactive electrophile such as allylic bromides and alkyl iodides. With these electrophiles good yields of H-phosphinic acid esters are generally obtained in a straightforward manner.

引用

页码：325 / 331

页数：7

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