The interaction between two antioxidants, sodium ascorbate and gallic acid: Radical intensity and apoptosis induction

被引：0
|
作者：
Sakagami, H [1 ]
Satoh, K [1 ]
机构：
[1] SHOWA UNIV,SCH PHARMACEUT SCI,ANALYT CTR,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
ANTICANCER RESEARCH | 1996年 / 16卷 / 3A期
关键词：
ascorbic acid; gallic acid; radical; ESR; interaction; apoptosis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ESR spectroscopy revealed that both the radical intensify and degradation rate of sodium ascorbate were increased with increasing pH. Gallic acid significantly reduced the radical intensity of sodium ascorbate, which in turn reduced the radical intensity of gallic acid. Sodium ascorbate inhibited the apoptosis-inducing activity of gallic acid, and gallic acid inhibited the intracellular incorporation of ascorbic acid. These data suggest that interaction between sodium ascorbate and gallic acid might modify their biological activity.
引用
收藏
页码：1231 / 1234
页数：4
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