Unexpected insights for anti-EGFR cancer therapy

被引:2
作者
Depeille, Philippe [1 ]
Warren, Robert S. [1 ]
Roose, Jeroen P. [1 ]
机构
[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
关键词
Chromosome Section; colorectal cancer; therapy; Ras; EGFR; METASTATIC COLORECTAL-CANCER; MUTATIONS; CETUXIMAB; IRINOTECAN; GROWTH;
D O I
10.18632/oncotarget.5115
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:18746 / 18747
页数:2
相关论文
共 7 条
[1]   Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer [J].
Cunningham, D ;
Humblet, Y ;
Siena, S ;
Khayat, D ;
Bleiberg, H ;
Santoro, A ;
Bets, D ;
Mueser, M ;
Harstrick, A ;
Verslype, C ;
Chau, I ;
Van Cutsem, E .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (04) :337-345
[2]   RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth [J].
Depeille, Philippe ;
Henricks, Linda M. ;
van de Ven, Robert A. H. ;
Lemmens, Ed ;
Wang, Chih-Yang ;
Matli, Mary ;
Werb, Zena ;
Haigis, Kevin M. ;
Donner, David ;
Warren, Robert ;
Roose, Jeroen P. .
NATURE CELL BIOLOGY, 2015, 17 (06) :804-+
[3]   Metastatic Colorectal Cancer: Current State and Future Directions [J].
Fakih, Marwan G. .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (16) :1809-+
[4]   EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma [J].
Navas, Carolina ;
Hernandez-Porras, Isabel ;
Schuhmacher, Alberto J. ;
Sibilia, Maria ;
Guerra, Carmen ;
Barbacid, Mariano .
CANCER CELL, 2012, 22 (03) :318-330
[5]   Association of KRAS G13D Tumor Mutations With Outcome in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy With or Without Cetuximab [J].
Tejpar, Sabine ;
Celik, Ilhan ;
Schlichting, Michael ;
Sartorius, Ute ;
Bokemeyer, Carsten ;
Van Cutsem, Eric .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (29) :3570-3577
[6]   Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer [J].
Van Cutsem, Eric ;
Lenz, Heinz-Josef ;
Koehne, Claus-Henning ;
Heinemann, Volker ;
Tejpar, Sabine ;
Melezinek, Ivan ;
Beier, Frank ;
Stroh, Christopher ;
Rougier, Philippe ;
van Krieken, J. Han ;
Ciardiello, Fortunato .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (07) :692-700
[7]   Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial [J].
Wang, Jack P. ;
Wu, Chen-Yi ;
Yeh, Yi-Cheng ;
Shyr, Yi-Ming ;
Wu, Ying-Ying ;
Kuo, Chen-Yu ;
Hung, Yi-Ping ;
Chen, Ming-Huang ;
Lee, Wei-Ping ;
Luo, Jiing-Chyuan ;
Chao, Yee ;
Li, Chung-Pin .
ONCOTARGET, 2015, 6 (20) :18162-18173