MK-10 clay catalyzed, one pot, three component and efficient synthesis of novel 4-(2′,5′-disubstituted-1′H-indol-3′-yl)-2,6-bis(2",5"-disubstituted-1"H-indol-3"-yl) pyridine-3,5-dicarbonitrile under conventional and microwave irradiation

被引:11
作者
Biradar, J. S. [1 ]
Sharanbasappa, B. [1 ]
机构
[1] Gulbarga Univ, Dept Chem, Gulbarga, Karnataka, India
关键词
indole; pyridine; microwave irradiation; solid support; conventional method; environmental benign; PYRIDINE; INDOLES;
D O I
10.1080/17518250903393890
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of title compounds were synthesized via a one pot, multicomponent reaction of 2,5-disubstituted indole 3-carboxaldehydes, 3-cyanoacetyl indoles, and ammonium acetate under microwave irradiation and conventional method in a short time to afford the corresponding products in high yields. It is an ideal, efficient, and environmental benign reaction. The structures of products thus obtained are confirmed by their melting point, IR, (HNMR)-H-1, and mass spectral data.
引用
收藏
页码:237 / 241
页数:5
相关论文
共 35 条
  • [11] SYNTHESIS CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL 5-((3-((2-(4-PHENYLTHIAZOLE-2-YL) HYDRAZONO) METHYL)-1H-INDOL-1YL) METHYL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
    Muralikrishna, S.
    Reddy, P. Raveendra
    Ravindranath, L. K.
    Rao, P. Jagadeeswara
    Raju, P. Ashok Gajapathi
    HETEROCYCLIC LETTERS, 2014, 4 (02): : 223 - 233
  • [12] A "One Pot," Environmentally Friendly, Multicomponent Synthesis of 2-Amino-5-cyano-4-[(2-aryl)-1H-indol-3-yl]-6-hydroxypyrimidines and Their Antimicrobial Activity
    Gupta, Ragini
    Jain, Anshu
    Madan, Yogita
    Menghani, Ekta
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 51 (05) : 1395 - 1403
  • [13] Catalytic synthesis and antimicrobial activity of N-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides
    Desai, Nisheeth C.
    Bhatt, Malay J.
    HETEROCYCLIC COMMUNICATIONS, 2016, 22 (03) : 131 - 136
  • [14] Iron(II) and Cobalt(II) Complexes with 2,6-Bis(1,4-Diphenyl-5-Hydroxy-1H-Pyrazol-3-yl)pyridine: Synthesis, Structures, and Spin States
    Nikovskii, I. A.
    Polezhaev, A., V
    Aleshin, D. Yu
    Mel'nikova, E. K.
    Dorovatovskii, P., V
    Nelyubina, Yu, V
    RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2020, 46 (05) : 317 - 325
  • [15] Synthesis of novel 2-amino-4-(5′-substituted 2′-phenyl-1H-indol-3′-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents
    Saundane, Anand R.
    Vijaykumar, Katkar
    Vaijinath, A. Verma
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (07) : 1978 - 1984
  • [16] Synthesis and Primary Antitumor Screening of 4-[5-(1H-Indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides
    Horishny, V. Ya.
    Matiychuk, V. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (07) : 1146 - 1152
  • [17] Synthesis and Primary Antitumor Screening of 4-[5-(1H-Indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides
    V. Ya. Horishny
    V. S. Matiychuk
    Russian Journal of Organic Chemistry, 2020, 56 : 1146 - 1152
  • [18] A facile one-pot, three-component synthesis of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives under microwave irradiation
    Jian-Feng Zhou
    Xiao-Jun Sun
    Feng-Wen Lou
    Meng Lv
    Lu-Lu Zhang
    Research on Chemical Intermediates, 2013, 39 : 1401 - 1408
  • [19] A facile one-pot, three-component synthesis of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives under microwave irradiation
    Zhou, Jian-Feng
    Sun, Xiao-Jun
    Lou, Feng-Wen
    Lv, Meng
    Zhang, Lu-Lu
    RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 39 (03) : 1401 - 1408
  • [20] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 5-((1H-INDOL-3-YL) METHYLENE)-2-((4-(3A, 4, 5, 6, 7, 7A-HEXAHYDRO-4, 7-METHANEBENZO[D] ISOOXAZOL-3-YL) PHENYL) IMINO)-3-METHYLTHIAZOLIDIN-4-ONE DERIVATIVES
    Vartale, S. P.
    Pawar, Y. D.
    Halikar, N. K.
    HETEROCYCLIC LETTERS, 2012, 2 (03): : 311 - 325