Nanomedicine development guided by FRET imaging

被引：63
作者：
Charron, Danielle M. [1 ,2 ,3 ]
Zheng, Gang [1 ,2 ,3 ,4 ]
机构：
[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada
[2] Univ Hlth Network, Techna Inst, Toronto, ON M5G 1L7, Canada
[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5G 1L7, Canada
[4] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
来源：
NANO TODAY | 2018年 / 18卷
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
Nanoparticle; Drug delivery; Self-assembly; Theranostics; Biophotonics; Cancer; RESONANCE ENERGY-TRANSFER; IN-VIVO; DRUG-DELIVERY; PROTEIN CORONA; QUANTUM-DOT; PHYSIOLOGICAL ENVIRONMENT; LABELED NANOPARTICLES; PERSONALIZED MEDICINE; TARGETED DELIVERY; CONTRAST AGENTS;
D O I：
10.1016/j.nantod.2017.12.006
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nano-bio interactions are dynamic, interrelated, and overwhelmingly influence nanomedicine efficacy. Molecular imaging techniques such as fluorescence are essential for illuminating the nano-bio interface to guide nanomedicine development. With advances in reliable labelling of nanoparticles with fluorophores, integrated Forster resonance energy transfer (FRET) provides responsive fluorescence linked to nanomedicine integrity and function. In this review, we provide an overview of developments in the application of integrated FRET for imaging nanomedicines during nano-bio interactions. Furthermore, we discuss technical considerations and a general methodology for maximizing information from integrated FRET imaging and advancing its use as a routine tool in nanomedicine research. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：124 / 136
页数：13
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