Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy

被引:63
|
作者
Cichoz-Lach, Halina [1 ]
Michalak, Agata [2 ]
机构
[1] Med Univ Lublin, Dept Gastroenterol, PL-20094 Lublin, Poland
[2] Med Univ Lublin, Fac Med 2, PL-20059 Lublin, Poland
关键词
Hepatic encephalopathy; Noncirrhotic hyperammonemic encephalopathy; Pathogeneses; Ammonia; Astrocyte; Oxidative stress; ACUTE LIVER-FAILURE; PROTEIN-TYROSINE NITRATION; INTRACRANIAL HYPERTENSION; WORKING PARTY; CIRRHOTIC-PATIENTS; OXIDATIVE STRESS; OTC DEFICIENCY; FINAL REPORT; AMMONIA; BRAIN;
D O I
10.3748/wjg.v19.i1.26
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatic encephalopathy is a medical phenomenon that is described as a neuropsychiatric manifestation of chronic or acute liver disease that is characterized by psychomotor, intellectual and cognitive abnormalities with emotional/affective and behavioral disturbances. This article focuses on the underlying mechanisms of the condition and the differences between hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy. Hepatic encephalopathy is a serious condition that can cause neurological death with brain edema and intracranial hypertension. It is assumed that approximately 60%-80% of patients with liver cirrhosis develop hepatic encephalopathy. This review explores the complex mechanisms that lead to hepatic encephalopathy. However, noncirrhotic hyperammonemic encephalopathy is not associated with hepatic diseases and has a completely different etiology. Noncirrhotic hyperammonemic encephalopathy is a severe occurrence that is connected with multiple pathogeneses. (C) 2013 Baishideng. All rights reserved.
引用
收藏
页码:26 / 34
页数:9
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