APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

被引：354

作者：

Goutte, C ^{[1
]}

Tsunozaki, M

Hale, VA

Priess, JR

机构：

[1] Amherst Coll, Dept Biol, Amherst, MA 01002 USA

[2] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Cellular Biol Program, Seattle, WA 98109 USA

[4] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

[5] Univ Washington, Dept Zool, Seattle, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 02期

关键词：

D O I：

10.1073/pnas.022523499

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates. Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.

引用

页码：775 / 779

页数：5

共 33 条

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