SINODAR ONE, an ongoing randomized clinical trial to assess the role of axillary surgery in breast cancer patients with one or two macrometastatic sentinel nodes

被引：43

作者：

Tinterri, Corrado ^{[1
]}

Canavese, Giuseppe ^{[1
]}

Bruzzi, Paolo ^{[2
]}

Dozin, Beatrice ^{[2
]}

机构：

[1] IRCCS Clin Inst Humanitas, Breast Unit, Ctr Canc, Rozzano, MI, Italy

[2] IRCCS AOU San Martino IST, Clin Epidemiol, Largo R Bensi 10, I-16132 Genoa, Italy

来源：

BREAST | 2016年 / 30卷

关键词：

Breast cancer; Sentinel lymph node biopsy (SLNB); Axillary lymph node dissection (ALND); Overall survival (OS); SINODAR ONE; LYMPH-NODES; DISSECTION; BIOPSY; WOMEN; METASTASES; OUTCOMES; UPDATE;

D O I：

10.1016/j.breast.2016.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sentinel lymph node biopsy alone is the current surgical axillary treatment for early-stage breast cancer patients with a negative sentinel lymph node (SLN). The possibility to omit axillary dissection also in presence of positive SLNs has been promoted by the American College of Surgeons Oncology Group (ASOCOG) Z0011 randomized trial. Several limitations and evidences of potential selection bias made this trial fairly controversial. Stronger evidence than currently available is needed on the safety of foregoing axillary dissection in well-defined populations of patients with positive SLNs. The Italian multicentre SINODAR ONE randomized trial here presented was designed with this aim. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

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