共 45 条
Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy
被引:52
作者:

Moritz, Tobias J.
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机构:
Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
Univ Calif Davis, Biophys Grad Grp, Davis, CA 95616 USA Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Taylor, Douglas S.
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h-index: 0
机构:
Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Krol, Denise M.
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h-index: 0
机构:
Univ Calif Davis, Biophys Grad Grp, Davis, CA 95616 USA
Univ Calif Davis, Dept Appl Sci, Davis, CA 95616 USA Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Fritch, John
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h-index: 0
机构:
Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Chan, James W.
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Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
机构:
[1] Univ Calif Davis, NSF Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Biophys Grad Grp, Davis, CA 95616 USA
[3] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA
[4] Univ Calif Davis, Dept Appl Sci, Davis, CA 95616 USA
基金:
美国国家科学基金会;
关键词:
D O I:
10.1364/BOE.1.001138
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Laser tweezers Raman spectroscopy (LTRS) was used to acquire the Raman spectra of leukemic T lymphocytes exposed to the chemotherapy drug doxorubicin at different time points over 72 hours. Changes observed in the Raman spectra were dependent on drug exposure time and concentration. The sequence of spectral changes includes an intensity increase in lipid Raman peaks, followed by an intensity increase in DNA Raman peaks, and finally changes in DNA and protein (phenylalanine) Raman vibrations. These Raman signatures are consistent with vesicle formation, cell membrane blebbing, chromatin condensation, and the cytoplasm of dead cells during the different stages of drug-induced apoptosis. These results suggest the potential of LTRS as a real-time single cell tool for monitoring apoptosis, evaluating the efficacy of chemotherapeutic treatments, or pharmaceutical testing. (C)2010 Optical Society of America
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页码:1138 / 1147
页数:10
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