Effect of neurocentral cartilage destruction on spinal growth in immature rabbits

被引：1

作者：

Wen, Jie ^{[1
,2
]}

Wang, Dahui ^{[1
]}

Fang, Ke ^{[2
]}

Xiao, Sheng ^{[2
]}

Ma, Ruixue ^{[1
]}

Liu, Hong ^{[2
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Orthoped, 399 Wanyuan Rd, Shanghai 201102, Peoples R China

[2] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Pediat Orthopaed, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2019年 / 47卷 / 02期

关键词：

Scoliosis; etiology; neurocentral cartilage; rabbits; computed tomography; Cobb angle; EXPERIMENTAL SCOLIOSIS; ROTATION; MODEL; EPIPHYSIODESIS; PATHOGENESIS; PEDICLE; MUSCLE;

D O I：

10.1177/0300060518820198

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective This study was performed to observe the effect of neurocentral cartilage (NCC) destruction on spinal growth in immature rabbits. Methods The NCC of the lumbar vertebrae of 24 4-week-old female rabbits was destroyed through posterolateral and anterior approaches, and three-dimensional computed tomography examinations were performed 3 months after the procedure. Results Scoliosis was successfully induced in all rabbits of both the anterior and posterolateral approach groups. The scoliosis exceeded 10 degrees in three rabbits, which exhibited coronal scoliosis of the spine, unequal length and thickness of the bilateral pedicles, and rotation of the vertebrae. Scoliosis was not observed in the control group. Conclusions Destruction of the unilateral NCC in immature rabbits can induce structural scoliosis, similar to the pathological features of human scoliosis. The Cobb angles are similar after NCC destruction by a posterolateral approach and under direct vision via the anterior approach.

引用

页码：951 / 961

页数：11

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