Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s

被引：469

作者：

Weber, Christine ^{[2
,3
,4
]}

Hoogenboom, Richard ^{[1
]}

Schubert, Ulrich S. ^{[2
,3
,4
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

[2] Univ Jena, Lab Organ & Macromol Chem IOMC, D-07743 Jena, Germany

[3] Univ Jena, Jena Ctr Soft Matter, D-07743 Jena, Germany

[4] Dutch Polymer Inst, NL-5612 AB Eindhoven, Netherlands

来源：

PROGRESS IN POLYMER SCIENCE | 2012年 / 37卷 / 05期

关键词：

Lower critical solution temperature; LCST; Cloud point; Poly(2-oxazoline)s; Poly(ethylene oxide); Poly(propylene oxide); Phase diagram; Thermo-responsive polymer; Coil to globule transition; OLIGO(ETHYLENE GLYCOL) METHACRYLATE; MEDIATED RADICAL POLYMERIZATION; PHASE-SEPARATION BEHAVIOR; METHYL-ETHER METHACRYLATE; AQUEOUS-SOLUTIONS; THERMORESPONSIVE POLYMER; GRAFT-COPOLYMERS; THERMOSENSITIVE POLY(2-ISOPROPYL-2-OXAZOLINE); 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE; DISSOCIATION TRANSITIONS;

D O I：

10.1016/j.progpolymsci.2011.10.002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This review covers the LCST behavior of two important polymer classes in aqueous solution, namely poly(2-oxazoline)s and systems whose thermo-responsiveness is based on their structural similarity to poly(ethylene oxide) (PEO). In order to elucidate the progress that has been made in the design of new thermo-responsive copolymers, experimental data that were obtained by different research groups are compared in detail. Copolymerization with hydrophilic or hydrophobic comonomers represents a suitable method to tune the coil to globule transition temperature of several homopolymers, and incorporation of other monomers provided further interesting features, such as pH responsiveness or sensing properties. In addition, living and controlled polymerization techniques enabled access to defined end groups and more advanced polymer architectures, such as graft copolymers or double responsive block copolymers. The effect of such structural variations on the temperature responsive behavior of the (co)polymers is discussed in detail. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：686 / 714

页数：29

共 146 条

[1] Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents [J].