Calcium helps neurons identify synaptic targets during development

被引：3

作者：

Berglund, Ken ^{[1
]}

Augustine, George J. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

NEURON | 2008年 / 59卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2008.07.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Correct wiring of brain circuitry during development involves the selective formation and retention of synaptic connections between neurons. In this issue of Neuron, Lohmann and Bonhoeffer show that dendritic filopodia can distinguish among prospective presynaptic axonal targets during development. Contact with the appropriate target triggers local calcium signals that stabilize the filopodia and tell them to form mature synapses.

引用

页码：186 / 187

页数：2

共 9 条

[1] Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion [J].

Coppolino, MG ;

Woodside, MJ ;

Demaurex, N ;

Grinstein, S ;

StArnaud, R ;

Dedhar, S .

NATURE, 1997, 386 (6627) :843-847

[2] Filopodial calcium transients promote substrate-dependent growth cone turning [J].

Gomez, TM ;

Robles, E ;

Poo, MM ;

Spitzer, NC .

SCIENCE, 2001, 291 (5510) :1983-1987

[3] Filopodia, spines, and the generation of synaptic diversity [J].

Jontes, JD ;

Smith, SJ .

NEURON, 2000, 27 (01) :11-14

[4] Local calcium transients regulate the spontaneous motility of dendritic filopodia [J].

Lohmann, C ;

Finski, A ;

Bonhoeffer, T .

NATURE NEUROSCIENCE, 2005, 8 (03) :305-312

[5] Transmitter-evoked local calcium release stabilizes developing dendrites [J].

Lohmann, C ;

Myhr, KL ;

Wong, ROL .

NATURE, 2002, 418 (6894) :177-181

[6] A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia [J].

Lohmann, Christian ;

Bonhoeffer, Tobias .

NEURON, 2008, 59 (02) :253-260

[7] REGULATION OF NEURONAL GROWTH CONE FILOPODIA BY INTRACELLULAR CALCIUM [J].

REHDER, V ;

KATER, SB .

JOURNAL OF NEUROSCIENCE, 1992, 12 (08) :3175-3186

[8] Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization [J].

Shi, Y ;

Ethell, IM .

JOURNAL OF NEUROSCIENCE, 2006, 26 (06) :1813-1822

[9] Evidence for a role of dendritic filopodia in synaptogenesis and spine formation [J].

Ziv, NE ;

Smith, SJ .

NEURON, 1996, 17 (01) :91-102

← 1 →