Advances in intrathecal drug delivery

被引：4

作者：

De Andres, Jose ^{[1
,2
,3
]}

Asensio-Samper, Juan M. ^{[2
,3
]}

Fabregat-Cid, Gustavo ^{[2
,3
]}

机构：

[1] Valencia Univ Med Sch, Anesthesia Div, Dept Surg Specialties, Valencia, Spain

[2] Valencia Gen Univ Hosp, Anesthesia Dept, Valencia 46014, Spain

[3] Valencia Gen Univ Hosp, Multidisciplinary Pain Management Dept, Valencia 46014, Spain

来源：

CURRENT OPINION IN ANESTHESIOLOGY | 2013年 / 26卷 / 05期

关键词：

baclofen; cerebrospinal fluid kinetics; chronic pain; intrathecal drug delivery system; local anesthesthetics; mixture of spinal drug targeting; opioids; spasticity; spinal drugs; ziconotide; CONSENSUS CONFERENCE-2012 RECOMMENDATIONS; CEREBROSPINAL-FLUID; CANCER PAIN; BACLOFEN THERAPY; FOLLOW-UP; PUMP; MANAGEMENT; SPASTICITY; INFUSION; MORPHINE;

D O I：

10.1097/ACO.0b013e3283625ec7

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Purpose of reviewTargeted intrathecal drug delivery systems (IDDS) are an option in algorithms for the treatment of patients with moderate-to-severe chronic refractory pain. This article is intended to review the literature regarding IDDS published over the last year, with special attention to the Polyanalgesic Consensus Conference 2012.Recent findingsThe recommendations made by the Polyanalgesic Consensus Conference 2012 are reviewed. Separate considerations of intrathecal drug therapy for neuropathic and nociceptive pain syndromes and the new concept of microdosing' are discussed in this article.SummaryThis review includes the recommendations for the use of IDDS, trialing, and recent reports of complications (especially, the occurrence of granulomas). In addition, the latest documents on cerebrospinal fluid and potential lines of future development are discussed.

引用

页码：594 / 599

页数：6

共 51 条

[1] Intrathecal combination of ziconotide and morphine for refractory cancer pain: A rapidly acting and effective choice [J].