Supramolecular Hydrogels Sustained Release Triclosan with Controlled Antibacterial Activity and Limited Cytotoxicity

被引：20

作者：

Ma, Dong ^{[1
]}

Wu, Ting ^{[2
]}

Zhang, Jinglin ^{[3
]}

Lin, Minsong ^{[4
,5
]}

Mai, Wenjie ^{[6
,7
]}

Tan, Shaozao ^{[3
]}

Xue, Wei ^{[1
]}

Cai, Xiang ^{[3
]}

机构：

[1] Jinan Univ, Dept Biomed Engn, Key Lab Biomat, Guangdong Higher Educ Inst, Guangzhou 510632, Guangdong, Peoples R China

[2] Guangzhou Liby Enterprise Grp Co Ltd, R&D Ctr, Guangzhou 510170, Guangdong, Peoples R China

[3] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

[4] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[5] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

[6] Jinan Univ, Dept Phys, Guangzhou 510632, Guangdong, Peoples R China

[7] Jinan Univ, Siyuan Lab, Guangzhou 510632, Guangdong, Peoples R China

来源：

SCIENCE OF ADVANCED MATERIALS | 2013年 / 5卷 / 10期

关键词：

Triclosan; Supramolecular Hydrogel; Sustained Release; Controlled Antibacterial Activity; Slight Cytotoxicity; NANOPARTICLES; DELIVERY; POLYMER; FABRICATION; COMPOSITE;

D O I：

10.1166/sam.2013.1602

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In order to reduce side effects of triclosan (TC), Pluronic F-127/alpha-cyclodextrin (PF/CD) supramolecular hydrogel was used as the carrier for TC, and a PF/CD/TC supramolecular hydrogel was prepared. The hydrogel property, antibacterial performance and cytotoxicity of this novel hybrid hydrogel were investigated. The results showed that the PF/CD/TC supramolecular hydrogel was characterized by an adjustable gelation time, mechanical strength and shear-shinning property with suitable CD concentration. The sustained release of TC could potentially reduce side effects of TC. With controlled antibacterial activity, the use of TC would be safer and more efficient. More importantly, this supramolecular hydrogel showed slight cytotoxicity, suggesting the great potential application as antibacterial tool for personal care products.

引用

页码：1400 / 1409

页数：10

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