Recent Developments in Catalytic Asymmetric Inverse-Electron-Demand Diels-Alder Reaction

Researchers discuss the latest developments in catalytic asymmetric inverse-electron-demand Diels-Alder (DA reaction. The catalytic asymmetric inverse-electron-demand Diels-Alder (IEDDA) reaction has emerged as a powerful and atom-economical tool for the stereoselective construction of functionalized six-membered rings with control of regio-, diastereo-, and enantioselectivity. It features mild reaction conditions, a tolerance of a diverse range of functional groups, and the easy construction of carbon-carbon and carbon-heteroatom bonds, which allows facile, stereospecific entry into the formation of functionalized ring systems. The high density of functional groups and up to four stereocenters of the resulting products renders them exceptionally versatile synthetic intermediates. Researchers discuss the latest efforts and advances in asymmetric IEDDA reaction through catalytic methodologies including the Lewis acidic metal complexes or organic molecules-catalyzed asymmetric IEDDA reaction through the LUMO-lowering strategy.