Graphene quantum dots for the inhibition of β amyloid aggregation

被引：116
作者：
Liu, Yibiao [1 ,2 ]
Xu, Li-Ping [1 ,2 ]
Dai, Wenhao [1 ,2 ]
Dong, Haifeng [1 ,2 ]
Wen, Yongqiang [1 ,2 ]
Zhang, Xueji [1 ,2 ]
机构：
[1] Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
[2] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
来源：
NANOSCALE | 2015年 / 7卷 / 45期
基金：
中国国家自然科学基金;
关键词：
ALZHEIMERS-DISEASE; FIBRIL FORMATION; PROTEIN FIBRILLOGENESIS; PEPTIDE AGGREGATION; CARBON NANOTUBES; OLIGOMERS; OXIDE; THERAPY; MODEL;
D O I：
10.1039/c5nr06282a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aggregation of A beta peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the A beta peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of A beta peptides. Compared to other carbon materials, the low cytotoxicity and great biocompatibility of GQDs give an advantage to the clinical research for AD. In addition, the GQDs may cross the blood-brain barrier (BBB) because of the small size. It is believed that GQDs may be therapeutic agents against AD. This work provides a novel insight into the development of Alzheimer's drugs.
引用
收藏
页码：19060 / 19065
页数：6
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