Emerging technologies for metabolite generation and structural diversification

被引：50

作者：

Cusack, Kevin P. ^{[1
]}

Koolman, Hannes F. ^{[2
]}

Lange, Udo E. W. ^{[3
]}

Peltier, Hillary M. ^{[2
]}

Piel, Isabel ^{[3
]}

Vasudevan, Anil ^{[2
]}

机构：

[1] AbbVie Biores Ctr, Worcester, MA 01605 USA

[2] AbbVie, Chicago, IL 60064 USA

[3] AbbVie Deutschland GmbH & Co KG, D-67061 Ludwigshafen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 20期

关键词：

Cytochrome P450; Metabolism; Electrochemistry; Fluorination; Metalloporphyrin; Microbial metabolism; Enzymatic transformation; Catalytic transformation; Biomimetic oxidation; OXIDATIVE DRUG-METABOLISM; C-H OXIDATION; BIOTRANSFORMATION PATHWAY; MICROBIAL TRANSFORMATIONS; ELECTROCHEMISTRY; CYTOCHROME-P450; IDENTIFICATION; FLOW; IMITATION; SPECTROMETRY;

D O I：

10.1016/j.bmcl.2013.08.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Multiple technologies have emerged for structural diversification and efficient production of metabolites of drug molecules. These include expanded use of enzymatic and bioorganic transformations that mimic biological systems, biomimetic catalysis and electrochemical techniques. As this field continues to mature the breadth of transformations is growing beyond simple oxidative processes due in part to parallel development of more efficient catalytic methods for functionalization of unactivated scaffolds. These technologies allow for efficient structural diversification of both aromatic and aliphatic substrates in many cases via single step reactions without the use of protecting groups. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5471 / 5483

页数：13

共 96 条

[1]

Alvarez-Lueje A, 2012, TOPICS ON DRUG METABOLISM, P221

[2] Product selectivity control induced by using liquid-liquid parallel laminar flow in a microreactor [J].