Mycophenolate mofetil combined with systemic corticosteroids prevents progression to chronic recurrent inflammation and development of `sunset glow fundus' in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease

Purpose: To evaluate the effectiveness and safety of mycophenolate mofetil (MMF) as first-line therapy combined with systemic corticosteroids in initialonset acute uveitis associated with Vogt-Koyanagi-Harada (VKH) disease. Methods: This prospective study included 38 patients (76 eyes). The main outcome measures were final visual acuity, corticosteroid-sparing effect, progression to chronic recurrent granulomatous uveitis and development of complications, particularly ` sunset glow fundus'. Results: The mean follow-up period was 37.0 +/- 29.3 (range 9-120 months). Visual acuity of 20/20 was achieved by 93.4% of the eyes. Corticosteroid-sparing effect was achieved in all patients. The mean interval between starting treatment and tapering to 10 mg or less daily was 3.8 +/- 1.3 months (range 3-7 months). Twentytwo patients (57.9%) discontinued treatment without relapse of inflammation. The mean time observed off of treatment was 28.1 +/- 19.6 months (range 1-60 months). None of the eyes progressed to chronic recurrent granulomatous uveitis. The ocular complications encountered were glaucoma in two eyes (2.6%) and cataract in five eyes (6.6%). None of the eyes developed ` sunset glow fundus', and none of the patients developed any systemic adverse events associated with the treatment. Conclusions: Use of MMF as first-line therapy combined with systemic corticosteroids in patients with initial-onset acute VKH disease prevents progression to chronic recurrent granulomatous inflammation and development of ` sunset glow fundus'.