Lack of association between high serum thyroid-stimulating hormone level and risk of papillary thyroid microcarcinomas

被引:24
作者
Sohn, Seo Young [1 ]
Kim, Hye Jeong [1 ]
Jang, Hye Won [1 ]
Kim, Sun Wook [1 ]
Chung, Jae Hoon [1 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Endocrinol & Metab, Seoul, South Korea
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2014年 / 36卷 / 01期
关键词
TSH; thyroid neoplasm; thyroid nodule; risk factors; papillary thyroid carcinoma; FINE-NEEDLE-ASPIRATION; THYROTROPIN CONCENTRATION; CANCER; NODULES; DISEASE; MANAGEMENT; TSH; ENLARGEMENT; MALIGNANCY; PREDICTOR;
D O I
10.1002/hed.23252
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
BackgroundHigh serum thyroid-stimulating hormone (TSH) is associated with thyroid carcinoma in patients with thyroid nodules. However, previous studies suggests that TSH is not involved in the pathogenesis of small thyroid carcinomas. We performed this study to evaluate serum TSH as a malignancy predictor in the assessment of small thyroid nodules. MethodsWe retrospectively analyzed 3791 patients who underwent thyroidectomy. We classified all patients into 3 to 5 groups by serum TSH or nodule size and analyzed the association of serum TSH and risk of papillary thyroid carcinoma (PTC). ResultsThe frequency of PTC increased as serum TSH increased. Serum TSH and older age were associated with the risk of PTC in multivariate analysis (p < .0001). In subgroup analysis, the risk of PTC increased as serum TSH increased with thyroid nodules > 1 cm (p < .05). ConclusionsSerum TSH may not be useful for clinical risk assessment of small thyroid nodules. (c) 2013 Wiley Periodicals, Inc. Head Neck36: 43-46, 2014
引用
收藏
页码:43 / 46
页数:4
相关论文
共 23 条
[1]   HIGH-FREQUENCY OF CANCER IN COLD THYROID-NODULES OCCURRING AT YOUNG AGE [J].
BELFIORE, A ;
GIUFFRIDA, D ;
LAROSA, GL ;
IPPOLITO, O ;
RUSSO, G ;
FIUMARA, A ;
VIGNERI, R ;
FILETTI, S .
ACTA ENDOCRINOLOGICA, 1989, 121 (02) :197-202
[2]   Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration [J].
Boelaert, K. ;
Horacek, J. ;
Holder, R. L. ;
Watkinson, J. C. ;
Sheppard, M. C. ;
Franklyn, J. A. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (11) :4295-4301
[3]   Ultrasound-guided fine-needle aspiration biopsy of thyroid masses [J].
Carmeci, C ;
Jeffrey, RB ;
McDougall, IR ;
Nowels, KW ;
Weigel, RJ .
THYROID, 1998, 8 (04) :283-289
[4]  
Ezzat Shereen, 1994, Archives of Internal Medicine, V154, P1838, DOI 10.1001/archinte.154.16.1838
[5]   Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role [J].
Fiore, E. ;
Rago, T. ;
Provenzale, M. A. ;
Scutari, M. ;
Ugolini, C. ;
Basolo, F. ;
Di Coscio, G. ;
Berti, P. ;
Grasso, L. ;
Elisei, R. ;
Pinchera, A. ;
Vitti, P. .
ENDOCRINE-RELATED CANCER, 2009, 16 (04) :1251-1260
[6]   Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice [J].
Franco, Aime T. ;
Malaguarnera, Roberta ;
Refetoff, Samuel ;
Liao, Xiao-Hui ;
Lundsmith, Emma ;
Kimura, Shioko ;
Pritchard, Catrin ;
Marais, Richard ;
Davies, Terry F. ;
Weinstein, Lee S. ;
Chen, Min ;
Rosen, Neal ;
Ghossein, Ronald ;
Knauf, Jeffrey A. ;
Fagin, James A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (04) :1615-1620
[7]   Thyrotropin Serum Concentrations in Patients with Papillary Thyroid Microcancers [J].
Gerschpacher, Marion ;
Goebl, Christian ;
Anderwald, Christian ;
Gessl, Alois ;
Krebs, Michael .
THYROID, 2010, 20 (04) :389-392
[8]  
HAY ID, 1992, SURGERY, V112, P1139
[9]   Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension [J].
Haymart, Megan R. ;
Glinberg, Simone L. ;
Liu, Jing ;
Sippel, Rebecca S. ;
Jaume, Juan C. ;
Chen, Herbert .
CLINICAL ENDOCRINOLOGY, 2009, 71 (03) :434-439
[10]   Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage [J].
Haymart, Megan Rist ;
Repplinger, Daniel John ;
Leverson, Glen E. ;
Elson, Diane F. ;
Sippel, Rebecca S. ;
Jaume, Juan Carlos ;
Chen, Herbert .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (03) :809-814