Ventromedial prefrontal cortex mediates sex differences in persistent cognitive drive for food
被引:17
作者:
Anderson, Lauren C.
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机构:
Boston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA
Harvard Med Sch, Dept Neurol, Massachusetts Gen Hosp, Charlestown, MA USABoston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA
Anderson, Lauren C.
[1
,2
]
Petrovich, Gorica D.
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Boston Coll, Dept Psychol, Chestnut Hill, MA 02167 USABoston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA
Petrovich, Gorica D.
[1
]
机构:
[1] Boston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA
[2] Harvard Med Sch, Dept Neurol, Massachusetts Gen Hosp, Charlestown, MA USA
Contemporary environments are saturated with food cues that stimulate appetites in the absence of hunger, which leads to maladaptive eating. These settings can induce persistent drive to eat, as learned behaviors can reappear after extinction. Behavioral paradigms of responding renewal provide a valuable framework to study how food cues contribute to the inability to resist palatable foods and change maladaptive eating habits. Using a rat model for this persistent food motivation, we determined sex differences in the causal function for the ventromedial prefrontal cortex (vmPFC) during context-mediated renewal of responding to food cues. Previously, we found behavioral sex differences (only males exhibited renewal) and differential recruitment within the vmPFC (increased Fos induction in males but decreased in females). Here, we used DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to silence vmPFC neurons in males and to stimulate vmPFC neurons in females specifically during renewal. Silencing vmPFC neurons in males disrupted renewal of responding to a food cue, while stimulating vmPFC neurons in females induced this behavior. These findings demonstrate sex differences in the vmPFC function in a model of food seeking relevant to environmentally driven appetites contributing to obesity and eating disorders.
机构:
Univ Wisconsin, Neurosci Training Program, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Mena, Jesus D.
;
Sadeghian, Ken
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Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Sadeghian, Ken
;
Baldo, Brian A.
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机构:
Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Univ Wisconsin, Neurosci Training Program, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
机构:
Univ British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, CanadaUniv British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, Canada
Mitchell, Sheona
;
Shaw, Dorothy
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h-index: 0
机构:
British Columbia Womens Hosp & Hlth Ctr, Vancouver, BC V6H 3N1, CanadaUniv British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, Canada
机构:
Univ Wisconsin, Neurosci Training Program, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Mena, Jesus D.
;
Sadeghian, Ken
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Sadeghian, Ken
;
Baldo, Brian A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
Univ Wisconsin, Neurosci Training Program, Madison, WI 53719 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USA
机构:
Univ British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, CanadaUniv British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, Canada
Mitchell, Sheona
;
Shaw, Dorothy
论文数: 0引用数: 0
h-index: 0
机构:
British Columbia Womens Hosp & Hlth Ctr, Vancouver, BC V6H 3N1, CanadaUniv British Columbia, Northern Med Program, Prince George, BC V2N 4Z9, Canada