Egg Consumption Modulates HDL Lipid Composition and Increases the Cholesterol-Accepting Capacity of Serum in Metabolic Syndrome

被引:79
作者
Andersen, Catherine J. [1 ]
Blesso, Christopher N. [1 ]
Lee, Jiyoung [1 ]
Barona, Jacqueline [1 ]
Shah, Dharika [2 ]
Thomas, Michael J. [2 ]
Fernandez, Maria Luz [1 ]
机构
[1] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA
[2] Wake Forest Sch Med, Winston Salem, NC 27157 USA
基金
美国食品与农业研究所;
关键词
HDL; Phospholipids; Cholesterol efflux; Metabolic syndrome; Eggs; Carbohydrate-restricted diet; HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; A-I SYNTHESIS; PHOSPHOLIPID CONTENT; EFFLUX CAPACITY; PARTICLE-SIZE; PLASMA; ABCA1; RISK; ATHEROSCLEROSIS;
D O I
10.1007/s11745-013-3780-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We recently demonstrated that daily whole egg consumption during moderate carbohydrate restriction leads to greater increases in plasma HDL-cholesterol (HDL-C) and improvements in HDL profiles in metabolic syndrome (MetS) when compared to intake of a yolk-free egg substitute. We further investigated the effects of this intervention on HDL composition and function, hypothesizing that the phospholipid species present in egg yolk modulate HDL lipid composition to increase the cholesterol-accepting capacity of subject serum. Men and women classified with MetS were randomly assigned to consume either three whole eggs (EGG, n = 20) per day or the equivalent amount of egg substitute (SUB, n = 17) throughout a 12-week moderate carbohydrate-restricted (25-30 % of energy) diet. Relative to other HDL lipids, HDL-cholesteryl ester content increased in all subjects, with greater increases in the SUB group. Further, HDL-triacylglycerol content was reduced in EGG group subjects with normal baseline plasma HDL-C, resulting in increases in HDL-CE/TAG ratios in both groups. Phospholipid analysis by mass spectrometry revealed that HDL became enriched in phosphatidylethanolamine in the EGG group, and that EGG group HDL better reflected sphingomyelin species present in the whole egg product at week 12 compared to baseline. Further, macrophage cholesterol efflux to EGG subject serum increased from baseline to week 12, whereas no changes were observed in the SUB group. Together, these findings suggest that daily egg consumption promotes favorable shifts in HDL lipid composition and function beyond increasing plasma HDL-C in MetS.
引用
收藏
页码:557 / 567
页数:11
相关论文
共 62 条
[1]   Is the decreased high-density lipoprotein cholesterol in the metabolic syndrome due to cellular lipid efflux defect? [J].
Alenezi, MY ;
Marcil, M ;
Blank, D ;
Sherman, M ;
Genest, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :761-764
[2]   Effect of Bariatric Surgery-Induced Weight Loss on SR-BI-, ABCG1-, and ABCA1-Mediated Cellular Cholesterol Efflux in Obese Women [J].
Aron-Wisnewsky, Judith ;
Julia, Zelie ;
Poitou, Christine ;
Bouillot, Jean-Luc ;
Basdevant, Arnaud ;
Chapman, M. John ;
Clement, Karine ;
Guerin, Maryse .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (04) :1151-1159
[3]   HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study [J].
Arsenault, Benoit J. ;
Lemieux, Isabelle ;
Despres, Jean-Pierre ;
Gagnon, Pascale ;
Wareham, Nicholas J. ;
Stroes, Erik S. G. ;
Kastelein, John J. P. ;
Khaw, Kay-Tee ;
Boekholdt, S. Matthijs .
ATHEROSCLEROSIS, 2009, 206 (01) :276-281
[4]   Metabolic and functional relevance of HDL subspecies [J].
Asztalos, Bela F. ;
Tani, Mariko ;
Schaefer, Ernst J. .
CURRENT OPINION IN LIPIDOLOGY, 2011, 22 (03) :176-185
[5]   Antiinflammatory properties of HDL [J].
Barter, PJ ;
Nicholls, S ;
Rye, KA ;
Anantharamaiah, GM ;
Navab, M ;
Fogelman, AM .
CIRCULATION RESEARCH, 2004, 95 (08) :764-772
[6]   Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome [J].
Blesso, Christopher N. ;
Andersen, Catherine J. ;
Barona, Jacqueline ;
Volek, Jeff S. ;
Fernandez, Maria Luz .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2013, 62 (03) :400-410
[7]   Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome [J].
Blesso, Christopher N. ;
Andersen, Catherine J. ;
Bolling, Bradley W. ;
Fernandez, Maria Luz .
FOOD & FUNCTION, 2013, 4 (02) :213-221
[8]  
BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[9]   PHOSPHOLIPIDS AND OTHER LIPIDS IN ANGIOGRAPHICALLY ASSESSED CORONARY-ARTERY DISEASE [J].
BOVET, P ;
DARIOLI, R ;
ESSINGER, A ;
GOLAY, A ;
SIGWART, U ;
KAPPENBERGER, L .
ATHEROSCLEROSIS, 1989, 80 (01) :41-47
[10]   FREE-RADICALS PROMOTE MODIFICATIONS IN PLASMA HIGH-DENSITY-LIPOPROTEIN - NUCLEAR-MAGNETIC-RESONANCE ANALYSIS [J].
BRADAMANTE, S ;
BARENGHI, L ;
GIUDICI, GA ;
VERGANI, C .
FREE RADICAL BIOLOGY AND MEDICINE, 1992, 12 (03) :193-203