SERPINB3 and B4: From biochemistry to biology

被引：77

作者：

Sun, Yu ^{[1
]}

Sheshadri, Namratha ^{[2
]}

Zong, Wei-Xing ^{[1
,3
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA

[2] NCI, Ctr Canc Res, Frederick, MD 21702 USA

[3] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 62卷

关键词：

SERPINB3; SERPINB4; Squamous cell carcinoma antigen; SCCA1; SCCA2; Inflammation; Cancer; SQUAMOUS-CELL CARCINOMA; UNFOLDED PROTEIN RESPONSE; EPITHELIAL-MESENCHYMAL TRANSITION; PSORIASIS-ASSOCIATED ANTIGEN; UTERINE CERVIX; CATHEPSIN-L; HEPATOCELLULAR-CARCINOMA; ATOPIC-DERMATITIS; TUMOR-ANTIGEN; REACTIVE-SITE;

D O I：

10.1016/j.semcdb.2016.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human SERPINB3 and SERPINB4 are evolutionary duplicated serine/cysteine protease inhibitors. Genomic analysis indicates that these paralogous genes were encoded from independent loci arising from tandem gene duplication. Although the two molecules share 92% identity of their amino acid sequences, they are distinct in the Reactive Center Loop (RCL) including a hinge region and catalytic sequences which accounts for altered substrate specificity. Elevated expression of the two molecules has been reported to contribute to numerous pathological conditions such as inflammatory diseases and cancer. In this review, we focus on summarizing the biochemical features of SERPINB3/B4 and discussing the mechanistic basis for their biological functions and implications in human diseases. (C) 2016 Published by Elsevier Ltd.

引用

页码：170 / 177

页数：8

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