"Click, Click, Cyclize": A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins

被引：70
作者：
Zhou, Aihua
Rayabarapu, Dinesh
Hanson, Paul R. [1 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 03期
关键词：
DIVERSITY-ORIENTED SYNTHESIS; DIELS-ALDER REACTIONS; SKELETAL DIVERSITY; DRUG DISCOVERY; SOLID SUPPORT; INHIBITORS; SCAFFOLDS; STRATEGY; MICHAEL; MOLECULES;
D O I：
10.1021/ol802467f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diversity-oriented synthesis (DOS) strategy termed "Click, Click, Cyclize" is reported. This approach relies on functional group (FG) pairing between a vinyl sulfonamide and an array of functional groups to synthesize skeletally diverse sultams. Several FG pairing pathways on central tertiary vinyl sulfonamide linchpins have been developed including intramolecular Heck, aza-Michael, ring-closing enyne metathesis, Pauson-Khand, and chemoselective oxidation/Baylis-Hillman reactions.
引用
收藏
页码：531 / 534
页数：4
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