Sirtuin deacetylases in neurodegenerative diseases of aging

被引：179
作者：
Herskovits, Adrianna Z. [1 ,2 ]
Guarente, Leonard [2 ]
机构：
[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
CELL RESEARCH | 2013年 / 23卷 / 06期
关键词：
sirtuin; histone deacetylase; Alzheimer's disease; Parkinson's disease; Huntington's disease; amyotrophic lateral sclerosis; spinal and bulbar muscular atrophy; AMYOTROPHIC-LATERAL-SCLEROSIS; BULBAR MUSCULAR-ATROPHY; FRONTOTEMPORAL LOBAR DEGENERATION; TRANSGENIC MOUSE MODEL; BETA-AMYLOID TOXICITY; SACCHAROMYCES-CEREVISIAE; HISTONE DEACETYLASE; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; CALORIE RESTRICTION;
D O I：
10.1038/cr.2013.70
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases including cancer, diabetes, inflammatory disorders and neurodegenerative disease. Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and spinal and bulbar muscular atrophy. Sirtuins can influence the progression of neurodegenerative disorders by modulating transcription factor activity and directly deacetylating proteotoxic species. Here, we describe sirtuin protein targets in several aggregate-forming neurodegenerative diseases and discuss the therapeutic potential of compounds that modulate sirtuin activity in these disorders.
引用
收藏
页码：746 / 758
页数：13
相关论文
共 123 条
  • [81] Attacking the flank: targeting new pathways in SBMA
    Merry, Diane E.
    [J]. NATURE MEDICINE, 2012, 18 (10) : 1461 - 1463
  • [82] SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
    Michan, Shaday
    Li, Ying
    Chou, Maggie Meng-Hsiu
    Parrella, Edoardo
    Ge, Huanying
    Long, Jeffrey M.
    Allard, Joanne S.
    Lewis, Kaitlyn
    Miller, Marshall
    Xu, Wei
    Mervis, Ronald F.
    Chen, Jing
    Guerin, Karen I.
    Smith, Lois E. H.
    McBurney, Michael W.
    Sinclair, David A.
    Baudry, Michel
    de Cabo, Rafael
    Longo, Valter D.
    [J]. JOURNAL OF NEUROSCIENCE, 2010, 30 (29) : 9695 - 9707
  • [83] SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
    Michishita, Eriko
    McCord, Ronald A.
    Berber, Elisabeth
    Kioi, Mitomu
    Padilla-Nash, Hesed
    Damian, Mara
    Cheung, Peggie
    Kusumoto, Rika
    Kawahara, Tiara L. A.
    Barrett, J. Carl
    Chang, Howard Y.
    Bohr, Vilhelm A.
    Ried, Thomas
    Gozani, Or
    Chua, Katrin F.
    [J]. NATURE, 2008, 452 (7186) : 492 - U16
  • [84] Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
    Min, Sang-Won
    Cho, Seo-Hyun
    Zhou, Yungui
    Schroeder, Sebastian
    Haroutunian, Vahram
    Seeley, William W.
    Huang, Eric J.
    Shen, Yong
    Masliah, Eliezer
    Mukherjee, Chandrani
    Meyers, David
    Cole, Philip A.
    Ott, Melanie
    Gan, Li
    [J]. NEURON, 2010, 67 (06) : 953 - 966
  • [85] Min SW, 2012, SOC NEUR 2012 NEUR M
  • [86] SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA
    Montie, Heather L.
    Pestell, Richard G.
    Merry, Diane E.
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (48) : 17425 - 17436
  • [87] A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia
    Morita, M
    Al-Chalabi, A
    Andersen, PM
    Hosler, B
    Sapp, P
    Englund, E
    Mitchell, JE
    Habgood, JJ
    de Belleroche, J
    Xi, J
    Brown, RH
    [J]. NEUROLOGY, 2006, 66 (06) : 839 - 844
  • [88] Mostoslavsky R, 2006, CELL, V124, P315, DOI 10.1016/J.CEL.2005.11.044
  • [89] SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
    Nakagawa, Takashi
    Lomb, David J.
    Haigis, Marcia C.
    Guarente, Leonard
    [J]. CELL, 2009, 137 (03) : 560 - 570
  • [90] Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Neumann, Manuela
    Sampathu, Deepak M.
    Kwong, Linda K.
    Truax, Adam C.
    Micsenyi, Matthew C.
    Chou, Thomas T.
    Bruce, Jennifer
    Schuck, Theresa
    Grossman, Murray
    Clark, Christopher M.
    McCluskey, Leo F.
    Miller, Bruce L.
    Masliah, Eliezer
    Mackenzie, Ian R.
    Feldman, Howard
    Feiden, Wolfgang
    Kretzschmar, Hans A.
    Trojanowski, John Q.
    Lee, Virginia M. -Y.
    [J]. SCIENCE, 2006, 314 (5796) : 130 - 133
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