The role of vascular endothelial growth factor in angiogenesis

被引：351
|
作者：
Ferrara, N [1 ]
Gerber, HP [1 ]
机构：
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
来源：
ACTA HAEMATOLOGICA | 2001年 / 106卷 / 04期
关键词：
angiogenesis; apoptosis; endothelium; retinopathy; tumor growth; tyrosine kinases; vascular endothelial growth factor;
D O I：
10.1159/000046610
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码：148 / 156
页数：9
相关论文
共 50 条
  • [41] Endogenous regulation of angiogenesis in the rat aorta model - Role of vascular endothelial growth factor
    Nicosia, RF
    Lin, YJ
    Hazelton, D
    Qian, XH
    AMERICAN JOURNAL OF PATHOLOGY, 1997, 151 (05): : 1379 - 1386
  • [42] The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development
    Liang, D
    Chang, JR
    Chin, AJ
    Smith, A
    Kelly, C
    Weinberg, ES
    Ge, RW
    MECHANISMS OF DEVELOPMENT, 2001, 108 (1-2) : 29 - 43
  • [43] Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells
    Rajesh, M
    Kolmakova, A
    Chatterjee, S
    CIRCULATION RESEARCH, 2005, 97 (08) : 796 - 804
  • [44] ROLE OF VASCULAR ENDOTHELIAL GROWTH-FACTOR IN RAT AORTIC ANGIOGENESIS AFTER INJURY
    NICOSIA, RF
    QUINN, T
    MOLECULAR BIOLOGY OF THE CELL, 1995, 6 : 2553 - 2553
  • [45] Vascular endothelial growth factor (VEGF)-A: Role on cardiac angiogenesis following myocardial infarction
    Zhao, Tieqian
    Zhao, Wenyuan
    Chen, Yuanjian
    Ahokas, Robert A.
    Sun, Yao
    MICROVASCULAR RESEARCH, 2010, 80 (02) : 188 - 194
  • [46] A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis
    Song, Min
    Yang, Hanshuo
    Yao, Shaohua
    Ma, Fanxin
    Li, Zheng
    Deng, Yaqi
    Deng, Hongxin
    Zhou, Qin
    Lin, Shuo
    Wei, Yuquan
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 357 (04) : 924 - 930
  • [47] Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis
    Ferrara, Napoleone
    CURRENT OPINION IN HEMATOLOGY, 2010, 17 (03) : 219 - 224
  • [48] Role of gremlin, an agonist of vascular endothelial growth factor receptor 2, in retinal angiogenesis
    Kim, Sang Jin
    Yun, Jihyun
    Kim, Ju-A
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [49] What is the role of vascular endothelial growth factor-related molecules in tumor angiogenesis?
    Nicosia, RF
    AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (01): : 11 - 16
  • [50] Vascular Endothelial Growth Factor: Much More than an Angiogenesis Factor
    Senger, Donald R.
    MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (03) : 377 - 379
12345