The role of vascular endothelial growth factor in angiogenesis

被引：351
|
作者：
Ferrara, N [1 ]
Gerber, HP [1 ]
机构：
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
来源：
ACTA HAEMATOLOGICA | 2001年 / 106卷 / 04期
关键词：
angiogenesis; apoptosis; endothelium; retinopathy; tumor growth; tyrosine kinases; vascular endothelial growth factor;
D O I：
10.1159/000046610
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码：148 / 156
页数：9
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